- Background: Diabetes Mellitus (DM), a clinical syndrome characterised by an increase in blood glucose concentration. Hyperglycemia induces changes in the platelet function in Diabetes Mellitus subjects. Platelet Indices include parameters such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT).
- Aim: To study the platelet indices in Diabetic Mellitus subjects, to compare the platelet indices in controlled with uncontrolled Diabetes Mellitus, to compare the platelet indices in Diabetes Mellitus with normal subjects.
- Materials and Methods: A cross – sectional study was conducted in (100 – Diabetes Mellitus & 100 Control(normal) subjects. Written Informed consent was obtained from the subjects. Each subject was asked to fill up the questionnaire on history of Diabetes Mellitus and general information. Blood parameters like Platelet Count, Mean Platelet Volume, Platelet Distribution Width, Plateletcrit, Fasting Blood Sugar, Post-Prandial Blood Sugar, HbA1c were estimated.
- Results: Among the Diabetic group, the FBS, PPBS and HbA1c was higher in uncontrolled DM than in DM subject under glycemic control, which was statistically significant. Platelet indices showed statistically significant difference between controlled and uncontrolled DM. MPV and PDW showed statistically significant difference between Diabetic and control group. Plateletcrit was not different between Diabetic and control group.
- Conclusion: Our study found that hyperglycemia leads to platelet hyperactivity. Thecontrol of glycemic status in each and everyDiabetic individual can prevent the development of micro vascular and macro vascular complications.
Keywords: Diabetes Mellitus, Mean Platelet Volume, Platelet Distribution Width, Plateletcrit